Virus-host interaction at single cell and organism level
Viruses affect all forms of life, from plants and bacteria to humans and undergo co-evolution together with their hosts. They may cause disease, or even assist in gene and antimicrobial therapies. Virus particles are ‘passive substances’ lacking energy providing processes, whereas virus infected cells are ‘active substances’ providing and consuming energy. They give rise to new self-organized structures, such as viral replication domains in the infected cells. A major challenge in the field is to understand how viruses utilize host cell functions for their multiplication, and how viruses are held in check by immunity at the cellular and systems levels. The meeting brings together scientists discussing different virus-host systems, ranging from latent, persistent to lytic infections. Participants explore how host factors that restrict or facilitate specific steps in infections can be identified, and how RNA viruses dynamically use pro- and antiviral factors in the course of error-prone replication. Deep knowledge of virus-host interactions provides a basis for the development of antiviral therapies. It also furthers a broader conceptional understanding of cell functions, based on the notion that viruses do interact with thousands of proteins in an infected cell, and are major drivers of host adaption in evolution.
The meeting will host advanced graduate students, post-docs and established scientists, and provide a free and interactive atmosphere for scientific exchange and discussions.